The risk assessment, management and remediation of Emerging Contaminants (ECs) constitute a pivotal subject in the global environmental domain. These contaminants are distinguished by their environmental persistence, bioaccumulative potential, and significant health hazards, emanating from complex sources across medical, agricultural, industrial and other sectors. Key categories include pharmaceuticals and personal care products (PPCPs), per- and polyfluoroalkyl substances (PFAS), endocrine-disrupting chemicals (EDCs), microplastics, etc. ECs have posed substantial impacts on environmental media (soil, water, atmosphere) and human health. As a critical challenge to global health and sustainable development, addressing ECs necessitates collaborative global actions. Through interdisciplinary integration, technological innovation, and policy optimization, enhanced monitoring, risk characterization, regulatory control and remedial measures should be implemented to safeguard the planetary environment and public health.